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The 10 Best Biotech Stocks Under 5 Dollars To Buy For May 2022! 

Noah Edis - February 07, 2022

Biotech stocks are some of the most volatile securities on any day, but many of them have a lot of potential for growth. If you’re a penny stock trader looking to get in on the ground floor of burgeoning biotech, you’re in luck. Check out our picks for the best biotech stocks under 5 bucks.

Many biotechnology stocks trade for less than $5 per share but get little technical analysis from investors who focus on larger-cap stocks.

Savvy small-cap day traders and long-term investors, however, are well aware of the profit potential of finding the right biotech penny stocks.

But where should you start your search?

Keep reading for our favorite biotech stocks trading under $5 and find out.

biotech stocks under 5

Best Biotech Penny Stocks Under $5

Atossa Therapeutics Inc. (NASDAQ: ATOS)

Atossa Therapeutics Inc. is a biopharmaceutical company in clinical development.

Its current focus is on breast cancer and COVID-19, two of medicine’s most well-funded disorders, which is why it’s one of our picks for the top biotech stocks.

Recently, Atossa Therapeutics’s lead drug candidate, Endoxifen, has shown potential for reducing tumor cell activity. 

These positive results may bode well for the future of the company and its ability to provide cutting-edge breast cancer treatments.

In addition, the company has a large market cap ($463 million) and a robust drug pipeline to help treat patients.

On September 30, Atossa Therapeutics announced it had begun enrolling patients in the AT-H201 clinical trial in Australia.

This ongoing study aims to develop a nebulized formulation for patients hospitalized with COVID-19 and “long haul” patients with post-infection pulmonary disease.

Atossa’s latest announcement is its advancement to Part B of its AT-H201 COVID-19 drug, with “extremely encouraging” results.

These details can be crucial to providing additional medication that directly targets a pandemic-driven market, providing a potential positive outturn for Atossa for years to come.

As a result of this year’s stock offerings, Atossa has amassed around $110 million, which may be enough to keep the company solvent through 2023.

In 2021, Atossa completed its strongest recovery since 2018, pushing for a 3-year high, only to tumble back to its early 2019 numbers.

All this means is Atossa is vulnerable to all the trappings of the typical biotech stock, which is rapid spikes during stock catalyst situations, followed by a long hiatus until news arrives.

The company planned several milestone targets for 2022, including the completion of its COVID-19 clinical study enrollment.

It also plans to continue the development of Endoxifen by running an Investigational New Drug Application (IND) for its Phase 2 study.

All this hubbub from Atossa means it’s a great stock that has good potential for the future, as long as it gets a positive turnover.


biotech stocks under 5

Lineage Cell Therapeutics, Inc. (NASDAQ: LCTX)

Lineage Cell Therapeutics, Inc. is a company that specializes in the development of new cell treatments and prescription therapeutics.

In December, the company connected with Swiss healthcare giant Roche Holding signing a collaboration deal with two of the latter’s units. 

The deal itself is to further push towards the management and commercialization of OpRegen, the company’s leading pipeline program for diseases such as advanced dry age-related macular degeneration (dry AMD) with geographic atrophy (GA).

This sudden surge created heavy interest in Lineage, which received a $50 million upfront payment for the deal and expects another $620 million if certain clinical milestones are met.

Roche is a big fish that is putting its money in a smaller penny stock company, giving Lineage a good potential for the years to come.

Its liquid assets of $68.7M are also expected to sustain its operations for the next two years.

All these numbers mean that the company has a good future ahead and once it clears all the milestones, it should build good value over time.

biotech stocks under 5

Orgenesis Inc (NASDAQ:ORGS)

Orgenesis Inc is personalized cell and gene therapy (CGTs) for different kinds of diseases, including cancer, genetic disorders, rare disorders, immunodeficiencies, and many more.

The Maryland biotech company has several therapies on its pipeline, including therapies for chronic pancreatitis and osteoarthritis available for clinical use.

Back in November, Orgenesis reported a 425% increase in its Q3 2021 compared year-over-year for the same quarter.

Orgenesis also has $33.44 million in liquidity and capital resources in 2020, compared to a loss of $2.9 million in 2019.

Much of the operating value of Orgenesis comes from its partnerships with several healthcare facilities all over the world for its cell therapy programs.

In late November, the company scheduled to receive up to €32 Million from the Greek government for its POCare Centers, with operational collaborations with Johns Hopkins University in Maryland and Hospital Infantil Universitario Niño Jesús in Madrid.

Unlike most biotech companies stuck waiting for positive outcomes from their clinical trials, Orgenesis has working partnerships that can generate net income for the company.

These collaborations provide significant cost reductions for its operations while accelerating development for cell and gene therapy pipelines.

These provide a potentially positive 2022 for Orgenesis from a development perspective, giving it good momentum.


biotech stocks under 5


Sesen Bio Inc. (NASDAQ: SESN)

Sesen Bio Inc. develops next-generation antibody-drug combination therapies to treat cancer.

Its shares spiked after the company announced on October 20 that the FDA had granted its request to hold a Type A meeting to discuss issues raised in the complete response letter (CRL) for Vicineum.

In August 2021, the company received its biggest downturn due to the outright rejection by the FDA of its originally promising bladder cancer treatment.

Sesen shares plummeted by as much as 78% in value since then but the company should be on its way to recover for 2022 once any news about its pipeline program Vicineum comes out in public.


biotech stocks under 5


Currently, vaccines are a popular topic within investing circles, and VBI Vaccines has benefited from this.

VBI is a pioneer in what is known as virus-like particle (VLP) technology, currently pushing the development of its VBI-2901 and VBI-2902, which are variants of the COVID-19 vaccine.

2901 is still in its preclinical stages, while 2902 is still in Phase 1 clinical trials, with human trials for the vaccine later in 2022 for the former, while the latter gets very positive historical market data published in the middle of 2021.

This immunology firm has promising preclinical vaccines in its pipeline.

Positive news about its vaccine variants should give VBI a good chance to move ahead, especially as the threat of COVID-19 continues to ravage the world.

If you’re new to investing in biotech, you might want to check out small-cap vaccine companies first, as this industry has withstood the test of time.

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biotech stocks under 5

Ready to build your portfolio? With Public.com you can follow other investors, discover companies that are inline with your beliefs, and invest into stocks and crypto with very little money! What are you waiting for? Check out Public Now!

More Top Biotech Stocks Under $5

Regulus Therapeutics Inc. (NASDAQ: RGLS)

Regulus Therapeutics Inc. is a biopharmaceutical company specializing in developing microRNA-targeting therapeutics to treat rare disorders and is currently advancing programs in renal and hepatic diseases.

This is a solid option if you want to give your penny stock portfolio exposure to the pharm industry.

Over the last four quarters, the company has surpassed the consensus of EPS estimates three times.

In September, the company announced that the 2021 Lasker-Koshland Special Achievement Award in Medical Science had been awarded to one of its directors, David Baltimore, Ph.D.

Additionally, $15.4 million was raised by Regulus Therapeutics’ at-the-market (ATM) facility, extending its expected cash runway into the fourth quarter of 2022.

The company is currently focusing on developing RGLS8429, its newest treatment candidate for Autosomal Dominant Polycystic Kidney Disease (ADPKD).


biotech stocks under 5


Kintara Therapeutics, Inc. (NASDAQ: KTRA)

Kintara Therapeutics, Inc. is a clinical-stage biotechnology firm that focuses on developing and commercializing new cancer therapies. 

The company is carrying out several clinical trials on brain tumors and solid tumors.

In January 2022, Kintara received a grant from the National Research Fund and Cancer Foundation Luxembourg to support its research towards the mechanism of action of VAL-083 on glioblastoma.

VAL-083 is the top program in its pipeline, reaching Phase 2 in several clinical trials against its many cancer-related activities, including brain tumor and ovarian cancer.

The grant should give the company some leeway into its studies but it needs more than this to have its value move from its all-time low.

Earlier in 2021, it widened access to clinical trials in the U.S. by opening new centers for glioblastoma (GBM) patients.

With future dividends excluded, Kintara has around 18,382 outstanding shares of Series C Preferred Stock exchangeable into 15.8 million shares of common equity to date. 


biotech stocks under 5


EntSera Bio Ltd. (NASDAQ: ENTX)

Entera Bio is a biotechnology company currently conducting clinical trials that attempt to enhance the absorption of large molecules and biologics in the GI tract using its proprietary technology.

Its stock price has risen 248% during the past year, resulting in solid gains for shareholders.

Entera Bio has a market cap of $133 million and spent $8.6 million last year, or 6.5 percent of its stock market value. 

Given that this is such a low number, it can potentially fund another expansion. 

The company can do this by issuing new shares or possibly taking out a loan.

Entera started 2022 with a positive end-of-phase 2 meeting with the FDA, agreeing to a Phase 3 12-month study with lumbar spine BMD.

If the company succeeds in its study, its EB613 drug should be the first oral anabolic treatment for osteoporosis and will provide solid potential gains for the company.


biotech stocks under 5 


Voyager Therapeutics (NASDAQ: VYGR)

Voyager Therapeutics Inc. is a clinical-stage gene therapy company working on therapies for severe neurological diseases.

A licensing and partnership agreement between the corporation and Neurocrine Biosciences Inc. covers the research, development, and commercialization of adeno-associated virus-based gene therapy products.

It also has strategic partnership agreements with ClearPoint Neuro Inc. and the University of Massachusetts as well as collaborations with Fujifilm Diosynth Biotechnologies and Thermo Fisher Scientific that help develop its gene therapy initiatives.

Voyager is now working on gene treatments using its unique AAV capsids, which have the potential to be more consistently on-target while reducing the danger of dose-limiting toxicities. 

In addition, the company, which has a large preclinical pipeline of second-generation and innovative programs, recently signed an arrangement with Pfizer.

Pfizer will pay Voyager $30 million for transgene-specific access to its innovative AAV capsids, plus option exercise fees, milestone payments, and product royalties totaling up to $600 million.

This deal will almost certainly result in further investments and expansion prospects for the organization.


biotech stocks under 5


Enzolytics Inc. (OTC: ENZC)

Enzolytics Inc. is a biotechnology company that develops and commercializes medications based on proprietary proteins to treat a variety of severe infectious diseases, including HIV/AIDS.

The company is working to commercialize the IPF’s licensing rights for Hepatitis C and AIDS treatment.

In addition, Enzolytics has produced a cell line that creates human monoclonal antibodies that target and destroy the HIV virus, as well as clinically proven anti-HIV treatments. 

The company recently announced a merger with BioClonetics Immunotherapeutics, which possesses the capability to generate completely human monoclonal antibodies against a variety of infectious diseases. 

This move will allow the company to expand its reach while continuing to produce on a massive scale, which could help its value to rise.


biotech stocks under 5


What You Should Know About the Biotech Industry

It was innovation that kept biotech penny stock so profitable throughout the greatest economic downturn in decades.

Thanks to the confluence of biological and technological breakthroughs, the number of assets moving into clinical trials continues to rise, and further waves of innovation are on the way.

For example, many biotech companies and the pharmaceutical sector as a whole are now working to combat the COVID-19 pandemic. 

Biotechs and pharma firms have a combined pipeline of more than 250 vaccine candidates and a similar number of medicines.

The Biotech industry changes in value according to the information that comes out regarding their products and pipelines.

Much of their value relies on stock catalysts, especially how their collaborations and their clinical trials work.

Biotech companies live and die by FDA approvals and rejections, which can help spike stock value during approval periods and drop values deeply during trial rejections.

Should You Buy Biotech Stocks?

The biotech sector is a growing industry, and for years to come, COVID-19’s biotech tailwinds will continue to blow.

As such, these biotech stocks under $5 can be great opportunities for all traders.

This field is extremely diverse and has a variety of applications worth investing in, including:

  • Cell therapy
  • Treating skin diseases
  • Biofuels
  • Agriculture 
  • And much more


Remember that if you’re looking for significant returns in the biotech industry, there’s a good chance you’ll stumble upon some investments that will leave you reeling from the losses along the way.

Biotech companies are more prone to volatility compared to other stocks, mostly due to their stock catalysts.

During periods of lull, biotech companies keep their values until stock market changes push them up or down.

So you should only put up as much money as you can afford to lose and do your due diligence before investing in biotech stocks.

biotech stocks under 5

Where to Buy Biotech Penny Stocks

Most of the biotech stocks mentioned above can be bought and sold on the New York Stock Exchange and NASDAQ.

There are several excellent stock market investing apps, but Public.com takes a more community-focused approach than others.

In addition to commission-free trading, the platform’s robust social features let you follow other traders and see why they’re buying or selling a stock.

Alternatively, you can buy from investment apps like Robinhood or WeBull.

However, not all the stocks within the biotech industry may be available for purchase on these platforms, so you might need to trade over the counter.

Biotech Stocks Under 5 Bucks: Final Words

In the ever-changing world of biotechnology, it’s essential to stay on top of the latest stock market news, developments, and trends so you don’t miss out on the next big innovation.

Demand for biotech products will continue to rise, and the companies on our list could potentially profit from it.

Regardless, make sure to do your due diligence before investing in any high risk biotech shares on the penny stock market.


Biotech Penny Stocks Frequently Asked Questions (FAQ)

Here are some of the most frequently asked questions online about biotech penny stocks.

What Is Biotech Stock?

A biotech stock is a stock related to a company that deals with the development of drugs and diagnostics technologies for disease treatment. 

Most biotech companies grow in value as they successfully develop treatment procedures, with stock growths reliant on breakthroughs, financial grants, and public-private partnerships.

Most biotech products undergo rigorous trials, making their approval very valuable.

Is It Good To Invest In Biotech?

Biotech is a great industry to invest in if you want a consistent stock that does not need a lot of monitoring. 

At the same time, you want to ensure that you get the freshest stock market news with biotech firms, as investors sell off immediately at the first sign of trouble. 

It’s best to invest in biotech if you’re looking to get short-term gains, making a difference either on daily stock movements or during stock appreciation.

What Is The Best Biotech Stock To Buy Right Now?

Among biotech penny stocks, Orgenesis Inc is the best on the list right now. 

Orgenesis has promising potential due to having pipeline programs that are ready for partnerships with different healthcare providers.

The firm is not as reliant on clinical trial approvals as other biotech companies, which means it has more consistency while building further onto its other pipelines.

Why Are Biotechnology Stocks Falling?

Biotech stocks can fall at a moment’s notice due to industry or company information known as stock catalysts.

While most firms have investment growths, sales numbers, and year-on-year growth reports as their catalysts, biotechnology firms rely on clinical trial results and FDA INDs.

If a biotech company receives a negative appreciation on their pipeline or gets clinical trial rejection, biotech stocks should experience sharp downturns in their value unless they have something else positive that can encourage investors to hold.

Is Biotech The Next Big Thing?

Biotech can be the next best thing, mostly due to the effects of the pandemic on the world.

Publicly traded companies in the biotech industry are racing to resolve not only the COVID-19 virus but also many chronic issues that can provide long-term relief to sufferers, including age-related disorders, cancer, and regenerative therapies.

With the right biotech company, investors should get the most advantage from a proper breakthrough.



Noah is a Canadian copywriter with interest in technology, AI, VR, and clean-tech. When he's not working, you'll likely find him playing sports or reading.